styrene cancer risk

However, increases in risk were largely confined to low-grade tumours, with ORs of 1.33 (95%CI 1.08 to 1.64) and 1.41 (95% CI 0.85 to 2.31) for ever exposure to any BTX and styrene, respectively, and a duration response pattern for any BTX. Several studies have reported an increased incidence of squamous-cell carcinomas and papillomas of the forestomach in rats and mice exposed to styrene oxide via gavage. Please sign below to tell the Villa Hills Board of Adjustments that you oppose the storage of this dangerous chemical at the TransMontaigne Plant on Route 8. The risk assessment concluded occupational risks are within acceptable ranges for most workers. Long-term chemical carcinogenesis bioassays showed that styrene caused lung cancers in … It could also lead to cancer and depression in some cases. The U.S. EPA does not have a cancer classification for styrene, but it has been the subject of their Integrated Risk Information System (IRIS) program.  |  Styrene is on the Proposition 65 list because it can cause cancer. Epub 2008 Sep 20. Boffetta P, Adami HO, Cole P, Trichopoulos D, Mandel JS. Determining risk requires consideration of whether, how, and how much a person is exposed to a substance or activity. The report identified 19 chemicals that could potentially cause cancer, including chloroform, formaldehyde, polychlorinated biphenyls (PCBs) and indium phosphide—the later … Although some studies suggest that styrene-exposed workers may be at increased cancer risk, the human evidence for styrene carcinogenicity is inconclusive. He faces a heightened risk of cancer because of his exposure to styrene, a chemical found in each of those products and in dozens of other consumer items, according to a U.S. government report. Epub 2012 Feb 16. The current systematic … However, the evidence is inconclusive due to multiple chemical exposures and inadequate information on the levels and duration of … The project, like all SIRC-funded research, serves to fulfill our product stewardship mission. Therefore, SCHER agrees with the conclusion of IARC (2002), that, based on the observations in human workers regarding blood styrene 7,8-oxide, DNA  |  Styrene Listed Effective April 22, 2016 as Known to the State of California to Cause Cancer Proposed Amendment to Section 25705, Specific Regulatory Levels Posing No Significant Risk: Styrene Notice of Amendment to Section 25705, No Significant Risk Level for Styrene There are no strong or consistent indications that styrene causes any form of cancer in humans. Teixeira JP, Gaspar J, Coelho P, Costa C, Pinho-Silva S, Costa S, Da Silva S, Laffon B, Pásaro E, Rueff J, Farmer P. Mutagenesis. NLM Clipboard, Search History, and several other advanced features are temporarily unavailable. Styrene can be found in air, soil, and water after release from the manufacture, use, and disposal of styrene-based products.  |  "Possibly carcinogenic and should be investigated more closely." He faces a heightened risk of cancer because of his exposure to styrene, a chemical found in each of those products and in dozens of other consumer items, according to a U.S. government report. 2009 Nov;51(11):1275-87. doi: 10.1097/JOM.0b013e3181ad49b2. Distinct areas of study included: cancer and toxicity to the nervous system, immune system, and reproduction and development. Styrene officially linked to cancer. 202-787-5996. In a German study of 1960 workers employed between 1931 and 1976 and followedbetween1956and1976,total mortality (74 observed and 96.5 ex-pected deaths) and cancer mortality (12 observed and 20.4 expected) were Styrene is a colorless liquid that evaporates easily. Further studies are needed to evaluate if the observed associations are likely to be causal. Styrene Information & Research Center However, EPA notes that there is no sufficiet evidence despite several epidemiology studies indicating there may be an association between styrene exposure and an increased risk of leukemia and lymphoma. Proposition 65 requires businesses to determine if they must provide a warning about exposure to listed chemicals. What is styrene? Styrene is widely used in the manufacture of synthetic rubber, resins, polyesters and plastics. Four styrene laden products to ditch. Does styrene cause cancer? of cancer risk following styrene ex-posure, include benzene, acryloni-trile, 1,3-butadiene, ethylbenzene, and dyes and pigments. No adequate human studies are available for styrene-7,8-oxide although this is the primary and active epoxide metabolite of styrene. Friday, June 1, 2018 After years of debate and evidence collection, the World Health Organization (WHO) has just reclassified styrene from being a “possible carcinogen” to a “probable carcinogen.” Styrene is a chemical building block of polystyrene, the plastic material used to make styrofoam and many other plastic products. Chung JK, Shen S, Jiang Z, Yuan W, Zheng J. Toxicol Lett. Since then, additional relevant research has been published. Download a printable fact sheet on the 2019 styrene risk assessment. Rueff J, Teixeira JP, Santos LS, Gaspar JF. Employees in the glass fibre reinforced plastics who have worked with the chemical styrene do not have -- as previously feared -- an increased incidence of cancer of … 2012 May 5;210(3):353-9. doi: 10.1016/j.toxlet.2012.02.008. The highest lifetime risk of getting cancer was observed in plastic injection device users (1.9 × 10−3) and then in shift managers (1.6 × 10−3). Using the same analogy, the risk of slipping and falling is minimal if the wet area is blocked off and the moisture is removed. Cytogenetic and DNA damage on workers exposed to styrene. 400 E Joppa Road, Suite 108 Previous epidemiology reviews of exposure to styrene and the risk of cancer considered studies published through 13 November 2013. The general population is unlikely to experience adverse health outcomes associated with styrene environmental or consumer exposures. In its pure form, styrene has a sweet smell. Styrene and the primary metabolite styrene-7,8-oxide are genotoxic and carcinogenic. Clin Chim Acta. Another important research result is a fivefold risk for a particular type of nasal cancer following styrene exposure. Styrene and the primary metabolite styrene-7,8-oxide are genotoxic and carcinogenic. The hazardous chemical Styrene is known to cause cancer in humans and is deadly if leaked. The limited evidence for the carcinogenicity of styrene in humans is based on studies of workers exposed to styrene that showed (1) in- creased mortality from or incidence of cancer of the lymphohemato- poietic system and (2) increased levels of DNA adducts and genetic damage in … 2009 Jan;399(1-2):8-23. doi: 10.1016/j.cca.2008.09.012. We use cookies to ensure that we give you the best experience on our website. Created for consumers, educators, the media, and industry employees, youknowstyrene.org is a reliable, one-stop source of information on styrene and styrene-based products. Mutagenesis. Last month (July 28) a committee convened by the National Academy of Sciences confirmed a federal interagency group’s conclusion that styrene, a chemical building block used to produce a wide variety of everyday products, can cause cancer. While the NTP describes evidence that styrene can cause cancer as “limited,” it reports that the occupational hazards include an increased risk for leukemia and lymphoma as well as genetic damage in white blood cells of workers exposed to the chemical. Simultaneous exposure to noise and styrene appears to increase potential adverse effects. DNA damage and susceptibility assessment in industrial workers exposed to styrene. An association with lung cancer is not consistently supported by other studies. 2018 Sep 1;144(9):797-801. doi: 10.1001/jamaoto.2018.1516. Independent scientists with relevant expertise prepared the various sections of the assessment. “Risk” is the likelihood that a hazard will cause harm to someone or something. ... Styrene isn’t known to leach out of hard plastics, but some evidence suggests that it can leach out of foam food containers and cups when food or drinks are hot – not when they’re cold. Please enable it to take advantage of the complete set of features! Styrene found in plastic products is linked with leukemia and nasal cancer risk, revealed research Aarhus University, Denmark. Styrene is an industrial chemical used to produce a number of different products, Micromachines (Basel). It maintains that the research in progress will “expand on the data considered in the NRC report, and provide more robust information for future styrene hazard and risk assessments.” Karayannis P, Petrakli F, Gkika A, Koumoulos EP. The Department of Occupational Medicine at Aarhus University in Denmark has concluded that styrene may cause cancer in humans. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. The average lifetime carcinogenic risk of styrene was 1.4 × 10−3; therefore, 100% (59 people) had a definite risk of getting cancer. The completed assessment was published by the Journal of Toxicology and Environmental Health, Part B: Critical Reviews in July 2019. 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